Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans

Nervous system function relies on precise synaptic connections.A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood.Taking advantage of known connectivity in C.elegans, we identified and studied

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In Vivo Genotoxicity and Toxicity Assessment of Sterigmatocystin Individually and in Mixture with Aflatoxin B1

Mycotoxins are natural food and feed contaminants produced by several molds.The primary mode of exposure in humans and animals is through mixtures.Aflatoxin B1 (AFB1) and sterigmatocystin (STER) are structurally related mycotoxins that share the same biosynthetic route.Few in vivo genotoxicity assays have 1041 been performed with STER.In the presen

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MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

Mycobacterium tuberculosis (Mtb) remains an important human pathogen.The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity.Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure Audio In Board of the cell envelope and dir

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